Formulation and Evaluation of Lornoxicam Microsponge Tablets for the Treatment of Arthritis

The purpose of this study was to design novel drug delivery system containing Lornoxicam microsponges. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges containing Lornoxicam and Eudragit RS 100 were prepared by quasi emulsion solvent diffusion method. The effects of drug to polymer ratios on physical characteristics of the microsponges were investigated. Compatibility of drug with adjuncts was studied by FT-IR. Production yield, loading efficiency, particle size analysis, surface morphology and in-vitro release studies were carried out. The microsponges were compressed into tablets. Mechanically strong tablets were obtained owing to the plastic deformation of sponge-like structure of microsponges. The effects of different stirring rates, amount of solvent, amount of emulsifier used on the physical characteristics of the microsponges were investigated. All the factors studied had an influence on the physical characteristics of the microsponges. In-vitro dissolution studies were done on all formulations and the results were kinetically evaluated and the release rate of Lornoxicam was found to be modified. This study presents a new approach based on microsponge drug delivery system.